Wales’ top duo both went out against higher-seeded opponents after last eight battles.
Evans, seeded seven, lost in straight games to England’s Sarah-Jane Perry 11-7, 11-4, 11-8 in 34 minutes.
The Rhyl-based player had come through her two previous games 3-2 on her return after an ankle injury then the COVID-19 suspension kept her off court for eight months.
Evans has had several battles with Perry in recent years, but this time her English rival came out on top.
But Evans – who had had only 17 minutes of court action before this week’s tournament -will have benefitted from vital game time.
Makin, seeded No 8, put up a defiant display against world No 1 and top seed Mohamed El Shorbagy.
The Egyptian took the first two games 11-4, 11-7 before Makin, who had won his first matches 3-0, fought back to win the third 11-8.
But after 70 gruelling minutes, Makin saw his tournament ended after losing the fourth game 11-7.